Losartan potassium Good Manufacturer supply High Quality 124750-99-8
- Molecular Formula:C22H22ClKN6OK
- Molecular Weight:461.008
- Appearance/Colour:white to off-white crystalline powder
- Vapor Pressure:1.55E-19mmHg at 25°C
- Melting Point:?69°C(lit.)
- Boiling Point:682 °C at 760mmHg
- Flash Point:366.3 °C
- PSA：89.61000
- Density:0.986g/mLat 25°C(lit.)
- LogP:3.89590
Losartan potassium (124750-99-8) Usage
Losartan potassium is the first potent and selective non-peptide angiotensin II (AT II) AT1 receptor antagonist introduced to the market as a once-daily oral antihypertensive. It is efficacious and long lasting in controlling blood pressure in spontaneous hypertensive rats, in patients with essential hypertension in addition to those patients with renal impairment. Since losartan functions by competitive antagonism at the level of receptor, which represents the most direct way of selectively inhibiting the renin-angiotensin system (RAS) independent of the source of AT II, its use has been reported to be free of the coughing side effect exhibited by the ACE inhibitors. In contrast to calcium channel blockers, losartan does not appear to cause ankle edema, headache and tachycardia. It is also reported to be in clinical trials for the treatment of heart failure. Losartan potassium, an angiotensin II receptor antagonist, is produced through a multi-step synthesis, involving the creation of a losartan precursor followed by its conversion to the potassium salt by reacting with potassium hydroxide in an alcoholic solvent. The purification of Losartan potassium, an angiotensin II receptor antagonist used to treat hypertension, typically involves multiple steps to remove impurities and ensure high purity. Common methods include recrystallization, where the compound is dissolved in a suitable solvent and then crystallized to eliminate unwanted byproducts. Chromatographic techniques, such as high-performance liquid chromatography (HPLC), can be used to separate impurities based on polarity and molecular interactions. Solvent extraction may also be employed to remove residual organic solvents and intermediates. Additionally, filtration and drying under controlled conditions help achieve the final pure product. Advanced techniques like ion-exchange purification and precipitation methods are sometimes utilized to enhance purity, especially in pharmaceutical-grade production.
How to get the best price on Losartan potassium?
Zibo Hangyu Biotechnology Development Co., Ltd is a quality supplier and manufacturer of Losartan potassium . You can buy high quality, low price Losartan potassium 124750-99-8 here.
Zibo Hangyu Biotechnology Development Co., Ltd. is a comprehensive chemical enterprise focusing on fine chemical products and pharmaceutical intermediates, integrating research and development, production and sales. The company is equipped with advanced equipment quality inspection and research center. At the same time, the company has excellent talents with rich experience in process development and quality control. To provide customers with total solutions from raw material processing to chemical synthesis systems. The company has established a standardized and perfect quality standard system to provide stable and high quality production and service.
Milestones
- 2012yearThe company was founded, began to engage in the production and supply of chemical raw materials
- 2014yearExpand the scale of production, pharmaceutical raw materials production workshop was established
- 2016yearCooperated with domestic and foreign chemical platforms to promote self-produced and high-end pharmaceutical intermediates
- 2019yearIn recent years to participate in the international pharmaceutical raw materials exhibitions
- 2023yearBusiness continues to expand, Production and Sales teams continue to grow
- 2026yearPlans to set up foreign branches
