Cabazitaxel Good Manufacturer supply High Quality 183133-96-2
- Molecular Formula:C45H57NO14
- Molecular Weight:835.946
- Appearance/Colour:white powder
- Melting Point:180 °C
- Boiling Point:870.7±65.0 °C(Predicted)
- PKA:11.20±0.46(Predicted)
- PSA：202.45000
- Density:1.31
- LogP:4.95870
Cabazitaxel (183133-96-2) Usage
In June 2010, the U.S. FDA approved cabazitaxel (also referred to as XRP6258 and RPR 116258A) in combination with the steroid prednisone for the treatment of metastatic Castration-Resistant Prostate Cancer (mCRPC) for patients who were previously treated with a docetaxelcontaining regimen for late-stage disease. Cabazitaxel is a semisynthetic analog of the natural product taxol, which is isolated from the bark of the yew tree. Cabazitaxel injection is used with prednisone to treat prostate cancer (cancer of the male reproductive organs) that has been treated with other medicines. Cabazitaxel injection belongs to a class of drugs called microtubule inhibitors. It works by slowing or stopping the growth of cancer cells. It is produced through a semi-synthetic process starting from a natural compound, 10-deacetylbaccatin III, extracted from the yew tree, and involves selective protection, methylation, and condensation reactions with an oxazolidinecarboxylic acid side chain. It's purification typically involves multiple chromatographic techniques, including reversed-phase high-performance liquid chromatography (RP-HPLC) and normal-phase chromatography, to remove impurities and by-products. Crystallization is also used to increase purity by selectively precipitating cabazitaxel while leaving unwanted compounds in solution. In addition, solvent extraction and recrystallization techniques help eliminate residual solvents and unwanted stereoisomers. Advanced purification steps may include preparative liquid chromatography and ultrafiltration to ensure pharmaceutical-grade quality.
How to get the best price on Cabazitaxel?
Zibo Hangyu Biotechnology Development Co., Ltd is a quality supplier and manufacturer of Cabazitaxel . You can buy high quality, low price Cabazitaxel 183133-96-2 here.
Zibo Hangyu Biotechnology Development Co., Ltd. is a comprehensive chemical enterprise focusing on fine chemical products and pharmaceutical intermediates, integrating research and development, production and sales. The company is equipped with advanced equipment quality inspection and research center. At the same time, the company has excellent talents with rich experience in process development and quality control. To provide customers with total solutions from raw material processing to chemical synthesis systems. The company has established a standardized and perfect quality standard system to provide stable and high quality production and service.
Milestones
- 2012yearThe company was founded, began to engage in the production and supply of chemical raw materials
- 2014yearExpand the scale of production, pharmaceutical raw materials production workshop was established
- 2016yearCooperated with domestic and foreign chemical platforms to promote self-produced and high-end pharmaceutical intermediates
- 2019yearIn recent years to participate in the international pharmaceutical raw materials exhibitions
- 2023yearBusiness continues to expand, Production and Sales teams continue to grow
- 2026yearPlans to set up foreign branches
